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王金良，中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所研究員，博士生導(dǎo)師，重要人獸共患病與烈性外來(lái)病創(chuàng)新團(tuán)隊(duì)首席科學(xué)家，國(guó)家自然科學(xué)基金“優(yōu)秀青年科學(xué)基金”獲得者，中國(guó)農(nóng)業(yè)科學(xué)院杰出青年英才。兼任動(dòng)物疫病防控全國(guó)重點(diǎn)實(shí)驗(yàn)室副主任、中國(guó)免疫學(xué)會(huì)獸醫(yī)免疫分會(huì)委員、中國(guó)畜牧獸醫(yī)學(xué)會(huì)生物技術(shù)學(xué)分會(huì)理事、中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物傳染病學(xué)分會(huì)青年委員、黑龍江省蛋白質(zhì)組學(xué)學(xué)會(huì)理事。自工作以來(lái)，一直專注于解析囊膜病毒入侵細(xì)胞的共性機(jī)制。搭建了病毒感染相關(guān)宿主分子篩選平臺(tái)，利用此平臺(tái)，發(fā)現(xiàn)mGluR2與Cav1.2 α1c、TfR1協(xié)同發(fā)揮狂犬病病毒、新冠病毒和流感病毒內(nèi)化受體功能，揭示一種新的病毒內(nèi)化共性機(jī)制；發(fā)現(xiàn)α-SNAP受干擾素調(diào)控表達(dá)并直接調(diào)控弗林蛋白酶活性，影響多種病毒囊膜蛋白切割進(jìn)而影響病毒內(nèi)化。以第一或通訊（含共同）作者在Nature Microbiology、Cell Discovery、Protein & Cell、mBio、PLoS Pathogens、Science China Life Sciences、Journal of Virology發(fā)表論文10篇。主持國(guó)家重點(diǎn)研發(fā)計(jì)劃課題、子課題、國(guó)家自然科學(xué)基金優(yōu)秀青年基金和青年基金等多項(xiàng)課題。

一、聯(lián)系方式

研究方向：獸醫(yī)微生物及其分子生物學(xué)

郵箱：wangjinliang@caas.cn

通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號(hào)，郵編150069

二、教育經(jīng)歷

2013.09 – 2016.06 中國(guó)農(nóng)業(yè)科學(xué)院研究生院  預(yù)防獸醫(yī)學(xué)專業(yè) 博士學(xué)位

2010.09 – 2013.06 中國(guó)農(nóng)業(yè)科學(xué)院研究生院  預(yù)防獸醫(yī)學(xué)專業(yè) 碩士學(xué)位

2006.09 – 2010.06 山西農(nóng)業(yè)大學(xué)  動(dòng)物醫(yī)學(xué)專業(yè) 學(xué)士學(xué)位

三、工作經(jīng)歷

2024.01 – 今 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 研究員 

2019.01 – 2023.12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 副研究員

2016.09 – 2020.11 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所 博士后

2016.07 – 2018.12 中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所  助理研究員

五、承擔(dān)項(xiàng)目

1.國(guó)家重點(diǎn)研發(fā)計(jì)劃課題，2022YFD1800102，病毒入侵與復(fù)制機(jī)制，2022/11-2025/12，450萬(wàn)元，課題主持

2.國(guó)家自然科學(xué)基金優(yōu)秀青年科學(xué)基金，32422087，囊膜病毒入侵細(xì)胞共性機(jī)制的發(fā)現(xiàn)，2025/01-2027/12，200萬(wàn)元，主持

3.國(guó)家自然科學(xué)基金青年科學(xué)基金，32202773，大電導(dǎo)Ca2+與電壓激活型K+通道α亞基介導(dǎo)狂犬病病毒感染的機(jī)制研究，2023/01-2025/12，30萬(wàn)元，主持

4.中國(guó)農(nóng)業(yè)科學(xué)院科技創(chuàng)新工程中心，CAAS-CSLPDCP-202401，禽流感和非洲豬瘟等畜禽重要疫病病原與宿主互作機(jī)制研究，2024/01-2028/12，100萬(wàn)元，子課題主持

5.國(guó)家重點(diǎn)研發(fā)計(jì)劃，2019YFE0107300，非洲豬瘟早期診斷試劑及亞單位疫苗研發(fā)，2020/07-2023/06，87萬(wàn)元，子課題主持

六、代表作論文

1. Jinliang Wang#, Zilong Wang#, Renqiang Liu#, Lei Shuai, Xinxin Wang, Jie Luo,Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen*,Zhigao Bu*. Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus. PLoS Pathogens (2018).

2. Jinliang Wang#, Lei Shuai#, Chong Wang#, Renqiang Liu#, Xijun He, Xianfeng Zhang, Ziruo Sun, Dan Shan, Jinying Ge, Xijun Wang, Ronghong Hua, Gongxun Zhong*, Zhiyuan Wen*, Zhigao Bu*. Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice. Protein Cell (2020).

3. Jinliang Wang#, Guan Yang#, Xinxin Wang#, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong and Zhigao Bu. SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells. Cell Discovery (2021).

4. Jinliang Wang#, Jie Luo#, Zhiyuan Wen, Xinxin Wang, Lei Shuai, Gongxun Zhong, Chong Wang, Ziruo Sun, Weiye Chen, Jinying Ge, Renqiang Liu, Xijun Wang, Zhigao Bu. Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor. mBio (2022).

5. Xinxin Wang, Jie Luo, Zhiyuan Wen, Lei Shuai, Chong Wang, Gongxun Zhong, Xijun He, Huizhen Cao, Renqiang Liu, Jinying Ge, Ronghong Hua, Ziruo Sun, Xijun Wang, Jinliang Wang*, and Zhigao Bu*. Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung. PLoS Pathogens (2022).

6. Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu*, and Jinliang Wang*. Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2. Journal of Virology, (2023). 

7. Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu*, and Jinliang Wang*. Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus. Journal of Virology, (2023).

8. Zixin Ni #, Jinliang Wang?#, Xiaofei Yu, Yifan Wang, Jingfei Wang, Xijun He, Chengjun Li, Guohua Deng, Jianzhong Shi, Huihui Kong, Yongping Jiang, Pucheng Chen, Xianying Zeng, Guobin Tian, Hualan Chen*, and Zhigao Bu*. Influenza virus uses mGluR2 as an endocytic receptor to enter cells. Nature Microbiology (2024).

9. Xiaofei Yu#, Zixin Ni#, Yifan Wang, Jingfei Wang, Guohua Deng, Jianzhong Shi, Huihui Kong, Yongping Jiang,Guobin Tian, Chengjun Li, Yoshihiro Kawaoka, Hualan Chen*, Jinliang Wang*. Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus, Science China Life Sciences (2025).

10. Ziruo Sun, Jinqiu Wang, Zhiyuan Wen, Lei Shuai, Wenjing Sun, Mengjie Yang, Jinyu Wang, Junyu Chen, Jinying Ge, Weiye Chen, Xijun Wang, Zhigao Bu*, Jinliang Wang*. Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization, Journal of Virology (2025).

11. Chong Wang#, Jinliang Wang#, Lei Shuai, Xiao Ma, Hailin Zhang, Renqiang Liu, Weiye Chen, Xijun Wang, Jinying Ge, Zhiyuan Wen*, and Zhigao Bu*. The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays an Important Role in Rabies Virus Entry. Viruses (2019).

12. Guangwen Wang#, Li Jiang#, Jinliang Wang#, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng,Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen*, and Chengjun Li*. Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus. mLife (2025).

13. Jinliang Wang#, Jie Yang#, Jinying Ge, Ronghong Hua, Renqiang Liu, Xiaofeng Li, Xijun Wang, Yu Shao, Encheng Sun, Donglai Wu, Chengfeng Qin, Zhiyuan Wen* and Zhigao Bu*. Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry. Virology Journal (2016).

14. 何倩倩, 王鑫鑫, 羅杰, 溫志遠(yuǎn), 王金良*, 步志高*. 紫外線抵抗相關(guān)基因UVRAG影響狂犬病病毒感染機(jī)制的研究, 中國(guó)預(yù)防獸醫(yī)學(xué)報(bào), (2021)

七、獲得獎(jiǎng)勵(lì)

中國(guó)農(nóng)業(yè)科學(xué)院“優(yōu)秀青年英才”（2022年）、“杰出青年英才”（2025）

中國(guó)畜牧獸醫(yī)學(xué)會(huì)第八屆井岡新秀（2025年）

2018年度中國(guó)農(nóng)業(yè)科學(xué)院優(yōu)秀博士后（2018年）