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1、個(gè)人簡(jiǎn)歷
薛美,預(yù)防獸醫(yī)學(xué)博士,生物學(xué)博士后,研究員,博士生導(dǎo)師,豬消化道傳染病創(chuàng)新團(tuán)隊(duì)執(zhí)行首席。黑龍江省高層次人才,黑龍江省優(yōu)秀青年基金獲得者,中國(guó)農(nóng)業(yè)科學(xué)院“優(yōu)秀青年”英才。任中國(guó)畜牧獸醫(yī)學(xué)會(huì)生物技術(shù)學(xué)分會(huì)理事、Science China Life Sciences、Journal of Virology等期刊審稿專家。主要從事豬腸道冠狀病毒的入侵機(jī)制、致病機(jī)制、免疫機(jī)制、疫苗研發(fā)及新型抗病毒策略等研究。主持國(guó)家自然科學(xué)基金面上項(xiàng)目、青年基金、“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題、黑龍江省自然科學(xué)基金優(yōu)秀青年項(xiàng)目和青年項(xiàng)目、中國(guó)博士后科學(xué)基金面上項(xiàng)目(一等資助)等;發(fā)表SCI論文20余篇(累積影響因子>100,單篇最高影響因子10.384)。獲得國(guó)家發(fā)明專利3項(xiàng),曾獲中國(guó)農(nóng)業(yè)科學(xué)院“優(yōu)秀博士后”稱號(hào),獲得中國(guó)畜牧獸醫(yī)學(xué)會(huì)頒發(fā)的“豬腸道病研究進(jìn)步獎(jiǎng)”、中國(guó)農(nóng)業(yè)科學(xué)院成果轉(zhuǎn)化獎(jiǎng)1項(xiàng)。指導(dǎo)畢業(yè)的2名碩士研究生均獲得“哈獸研一等獎(jiǎng)學(xué)金”。
2、聯(lián)系方式
研究方向:動(dòng)物疫苗與分子免疫學(xué)
電話:0451-51051715
郵箱:xuemei_23@126.com
通訊地址:哈爾濱市香坊區(qū)哈平路678號(hào)
3、教育經(jīng)歷
2003.09-2007.06 青島農(nóng)業(yè)大學(xué) 動(dòng)物醫(yī)學(xué)專業(yè) 學(xué)士
2007.09-2010.06 中國(guó)農(nóng)業(yè)科學(xué)院研究生院(哈獸研)預(yù)防獸醫(yī)學(xué)專業(yè) 碩士
2010.09-2013.06 中國(guó)農(nóng)業(yè)科學(xué)院研究生院(哈獸研)預(yù)防獸醫(yī)學(xué)專業(yè) 博士
4、工作經(jīng)歷
2014.12-2017.12 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所 博士后 助理研究員
2018.01-2022.12 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所 副研究員
2023.01-至今 中國(guó)農(nóng)科院哈爾濱獸醫(yī)研究所 研究員
5、承擔(dān)項(xiàng)目
(1)國(guó)家自然科學(xué)基金面上項(xiàng)目(32473003,2025.01-2028.12),50萬(wàn)元,項(xiàng)目負(fù)責(zé)人;
(2)“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題(2025YFD1800903,2025.12-2028.11),150萬(wàn)元,子課題負(fù)責(zé)人;
(3)中國(guó)農(nóng)業(yè)科學(xué)院科技創(chuàng)新工程科學(xué)中心重點(diǎn)任務(wù)(CAAS-CSLPDCP-202401,2024.1-2028.12),100萬(wàn)元,課題骨干;
(4)“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題(2021YFD1801103-5,2021.12-2024.11),150萬(wàn)元,子課題負(fù)責(zé)人;
(5)“十四五”國(guó)家重點(diǎn)研發(fā)計(jì)劃(2023YFB4705600,2023.12-2026.11),25.74萬(wàn)元,子課題負(fù)責(zé)人;
(6)國(guó)家自然科學(xué)基金青年項(xiàng)目(31802198,2019.01-2021.12),25萬(wàn)元,項(xiàng)目負(fù)責(zé)人;
(7)黑龍江省自然科學(xué)基金優(yōu)秀青年項(xiàng)目(YQ2022C041,2022.07-2025.07),10萬(wàn)元,項(xiàng)目負(fù)責(zé)人;
(8)黑龍江省自然科學(xué)基金青年項(xiàng)目(QC2017031,2017.10-2020.10),5萬(wàn)元,項(xiàng)目負(fù)責(zé)人;
(9)中國(guó)博士后科學(xué)基金面上資助一等資助(2015M570185,2015.03-2017.12),8萬(wàn)元,項(xiàng)目負(fù)責(zé)人;
(10)國(guó)家自然科學(xué)基金面上項(xiàng)目(31772718,2018.1-2021.12),61萬(wàn)元,項(xiàng)目參與人。
6、代表性論文與著作
(1) Wang C#, Xue M#, Wu P, Wang H, Liu Z, Wu G, Liu P, Wang K, Xu W, Feng L*. Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway. Science China Life Sciences. 2022 Jul; 65(7):1413-1429. doi: 10.1007/s11427-021-1967-x.(IF:10.384)
(2) Li Z, Chen J, Chen Y, Hu S, Li H, Li L, Xue M*, Feng L*. Tight junction protein claudin-1 is a novel internalization factor for swine enteric coronaviruses infection. mBio. 2026 Feb 11;17(2):e0349625. doi: 10.1128/mbio.03496-25.(IF:4.7)
(3) Ji Z#, Zhang X#, Xue M#, Chen J, Shi D, Shi H, Zhang H, Zhang L, Feng T, Zhu X, Li X, Liu D, Wang M, Zeng M, Feng L*. Successful in vitro propagation of porcine bocavirus: Demonstrating dual respiratory-enteric tropism and pathogenicity. PLoS Pathogens. 2025 Nov 3;21(11):e1013631. doi: 10.1371/journal.ppat.1013631. (IF:4.9)
(4) Cong G, Li H, Li L, Chen J, Fu F, Deng H, Hu Z, Wang L, Li Y, Xue M*, Feng L*. The newly developed porcine-origin parainfluenza virus PIV5-JS17 serves as an exogenous gene delivery system for swine. Journal of Virology. 2026 Feb 17;100(2):e0185825. doi: 10.1128/jvi.01858-25.(IF:3.8)
(5) He H#, Li Y#, Chen Y, Chen J, Li Z, Li L, Shi D, Zhang X, Shi H, Xue M*, and Feng L*. NLRP1 restricts porcine deltacoronavirus infection via IL-11 inhibiting the phosphorylation of the ERK signaling pathway. Journal of Virology. 2024 Mar 19;98(3):e0198223. doi: 10.1128/jvi.01982-23. (IF:5.4)
(6) He H, Wang W, Li L, Zhang X, Shi H, Chen J, Shi D, Xue M*, Feng L*. Activation of the NLRP1 inflammasome and its role in transmissible gastroenteritis coronavirus infection. Journal of Virology. 2023 Jun 29;97(6):e0058923. doi: 10.1128/jvi.00589-23.(IF:5.4)
(7) Xue M, Wang W, He H, Li L, Zhang X, Shi H, Liu P*, Feng L*. Different mechanisms are utilized by coronavirus transmissible gastroenteritis virus to regulate interferon Lambda 1 and interferon Lambda 3 production. Journal of Virology. 2022 Dec 21; 96(24):e0138822. doi: 10.1128/jvi.01388-22.(IF:6.549)
(8) Xue M, Fu F, Ma Y, Zhang X, Li L, Feng L*, Liu P*. The PERK arm of the unfolded protein response negatively regulates transmissible gastroenteritis virus replication by suppressing protein translation and promoting type I IFN production. Journal of Virology. 2018 Jul 17; 92:e00431-18. doi: 10.1128/JVI.00431-18.(IF: 4.324)
(9) Xue M and Feng L. The role of unfolded protein response in coronavirus infection and its implications for drug design. Frontiers in Microbiology. 2021 Dec 24; 12:808593. doi: 10.3389/fmicb.2021.808593. (IF: 6.064)
(10) Zhao L, Li L, Xue M, Liu X, Jiang C, Wang W, Tang L, Feng L, Liu P*. Gasdermin D inhibits coronavirus infection by promoting the noncanonical secretion of beta interferon. mBio. 2021 Feb 22;13(1):e0360021.doi: 10.1128/mbio.03600-21.(IF:7.786)
(11) Xue M, Zhao J, Ying L, Fu F, Li L, Ma Y, Shi H, Zhang J, Feng L, Liu P*. IL-22 Suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway. Antiviral research. 2017, 142:68-75. (IF: 4.307)
7、獲得專利
(1)穩(wěn)定表達(dá)全豬源抗PEDV中和抗體PC10-IgA的CHO細(xì)胞系及其構(gòu)建方法和應(yīng)用,發(fā)明專利號(hào):ZL201810235163.6-國(guó)家知識(shí)產(chǎn)權(quán)局
(2)一種利用單個(gè)B細(xì)胞PCR技術(shù)生產(chǎn)全豬源單克隆抗體的方法,發(fā)明專利號(hào):ZL2016 10437224.8-國(guó)家知識(shí)產(chǎn)權(quán)局
8、獲得獎(jiǎng)勵(lì)
(1)被評(píng)為中國(guó)農(nóng)業(yè)科學(xué)院2017年度“優(yōu)秀博士后”;
(2)榮獲中國(guó)畜牧獸醫(yī)學(xué)會(huì)頒發(fā)的“豬腸道病研究進(jìn)步獎(jiǎng)”;
(3)獲得中國(guó)農(nóng)業(yè)科學(xué)院成果轉(zhuǎn)化獎(jiǎng)-科技開(kāi)發(fā)獎(jiǎng)(9/13)。
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