掃一掃 關(guān)注我
1、個人簡歷
孫留克,男,1988年出生,碩士生導(dǎo)師,馬傳染病與慢病毒病創(chuàng)新團隊副研究員。主要從事逆轉(zhuǎn)錄病毒和馬流感病毒復(fù)制及其致病機制研究。近年來在SCI檢索期刊上發(fā)表論文8篇。
2、聯(lián)系方式
單位:中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所
地址:黑龍江省哈爾濱市南崗區(qū)哈平路678號
電話:0451-51051751
郵箱:sunlk0916@126.com
3、教育經(jīng)歷
2007.9-2011.7 新鄉(xiāng)醫(yī)學(xué)院,生命科學(xué)與技術(shù)學(xué)院,學(xué)士
2011.9-2014.7 中國農(nóng)業(yè)科學(xué)院研究生院,中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所,碩士
2015.3-2019.7 哈爾濱工業(yè)大學(xué),生命科學(xué)與技術(shù)學(xué)院,博士
4、工作經(jīng)歷
2019.9-2023.11 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所,馬傳染病與慢病毒病創(chuàng)新團隊,博士后
2023.12-至今 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所,馬傳染病與慢病毒病創(chuàng)新團隊,副研究員
5、承擔(dān)主要項目
1. 國家重點研發(fā)計劃項目“草食家畜新發(fā)和重要疫病新型疫苗研究”(2023YFD1802501)課題的子課題-“馬流產(chǎn)沙門氏疫苗研發(fā)”,2023年12月-2027年12月、32萬元,子課題主持。
6、代表性論文與著作
1. Sun L, Guo X, Yu M, Wang XF, Ren H, Wang X*. Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction. Nat Commun. 2024 Dec 30;15(1):10805. doi: 10.1038/s41467-024-55034-y. PMID: 39737943; PMCID: PMC11686252.
2. Na L#, Sun L#, Yu M#, Zhang Y, Zhang Y, Zhang Z, Zhang H, Qi T, Guo W, Guo X, Wang S, Wang J, Lin Y, Wang X. Avian ANP32A incorporated in avian influenza A virions promotes interspecies transmission by priming early viral replication in mammals. Sci Adv. 2024 Feb 2;10(5):eadj4163. doi: 10.1126/sciadv.adj4163. Epub 2024 Jan 31. PMID: 38295177; PMCID: PMC10830118.
3. Sun L#, Kong H#, Yu M#, Zhang Z, Zhang H, Na L, Qu Y, Zhang Y, Chen H, Wang X. The SUMO-interacting motif in NS2 promotes adaptation of avian influenza virus to mammals. Sci Adv. 2023 Jul 14;9(28):eadg5175. doi: 10.1126/sciadv.adg5175. Epub 2023 Jul 12. PMID: 37436988; PMCID: PMC10337910.
4. Yu M#, Sun L#, Zhang Z, Zhang Y, Zhang H, Na L, Wang X. KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity. Microbiol Spectr. 2022 Feb 23;10(1):e0207321.(共第一)
5. Sun L, Büeler H. Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52?kDa) PINK1. Biochem Biophys Res Commun. 2019 Sep 17;517(2):376-382。
6. Agnihotri SK#, Sun L#, Yee BK, Shen R, Akundi RS, Zhi L, Duncan MJ, Cass WA, Büeler H. PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice. Behav Brain Res. 2019 May 2;363:161-172.
7. Sun L, Shen R, Agnihotri SK, Chen Y, Huang Z, Büeler H. Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death. Sci Rep. 2018 Jan 10;8(1):383.
8. Lin YZ#, Sun LK#, Zhu DT, Hu Z, Wang XF, Du C, Wang YH, Wang XJ, Zhou JH. Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology. 2016 Aug;495:112-21.
掃一掃 關(guān)注我