av一区二区三区人妻,青青在线视频播放观看,四虎成人精品永久免费网址,国产亚洲免费自拍视频,国产日韩欧美亚洲天堂,国产精品人妻一码二码,天天舔天天摸天天狠,92午夜福利1000免费,黄色高清网站在线看

1、個人簡介

黨光輝，男，博士，副研究員，碩士生導(dǎo)師，中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所動物細菌病創(chuàng)新團隊成員，中國防癆協(xié)會人獸共患結(jié)核病專業(yè)分會委員。主持十四五國家重點研發(fā)計劃子課題、國家自然科學(xué)基金等項目3項。以第一（含共第一）和通訊作者發(fā)表文章16篇，獲得授權(quán)發(fā)明專利2項。協(xié)助培養(yǎng)研究生12名。目前主要從事結(jié)核病和副結(jié)核病致病機制研究、亞單位疫苗和診斷制品的開發(fā)。

2、聯(lián)系方式

研究方向：獸醫(yī)微生物及其分子生物學(xué)

電話：0451-51051732

郵箱：dangguanghui@caas.cn

通訊地址：黑龍江省哈爾濱市香坊區(qū)哈平路678號綜合樓5008，150069

3、教育經(jīng)歷

2004.09-2009.06 河南科技學(xué)院  動物醫(yī)學(xué)  學(xué)士

2010.09-2012.06 福建農(nóng)林大學(xué)  基礎(chǔ)獸醫(yī)學(xué)  碩士

2014.09-2018.01 中國農(nóng)業(yè)科學(xué)院研究生院  預(yù)防獸醫(yī)學(xué)  博士

4、工作經(jīng)歷

2013.07-2014.08 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所  科研助理

2018.11-2023.07 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所  博士后

2022.01-至今 中國農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所  副研究員

5、 承擔(dān)的項目

1. 國家自然科學(xué)基金青年項目，32002256，Rv3194c蛋白酶在結(jié)核分枝桿菌逃逸IgG介導(dǎo)的免疫殺傷中的作用機制研究，2021-01-01 至 2023-12-31，24萬元， 主持

2. “十四五”國家重點研發(fā)計劃子課題，2023YFD1801302，“瀕危和青藏高原動物結(jié)核病和副結(jié)核病診斷技術(shù)與產(chǎn)品研發(fā)”2023-12-01至2027-12-31，60萬元，主持

3. 中央級公益性科研院所基本科研業(yè)務(wù)費項目，1610302024002，XthA磷脂酶影響分枝桿菌分枝菌酸合成的機制研究，2024-01-01至2024-12-31，16萬元，主持

4. 國家自然科學(xué)基金面上項目，32273005，結(jié)核分枝桿菌Rv2569c半胱氨酸蛋白酶介導(dǎo)的Caspase非依賴性巨噬細胞凋亡的機制研究，2023-01-01至2026-12-31，54萬元，參與

6、代表論文與著作

1. Zang Xinxin, Zhang Jiajun, Jiang Yanyan, Feng Tingting, Cui Yingying, Wang Hui, Cui Ziyin, Dang Guanghui*, Liu Siguo*. Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin. PLoS Pathogens, 2024 20(5): e1012214.

2. Shao Mingzhu, Cui Ning, Tang Yangyang, Chen Fanruo, Cui Yingying, Dang Guanghui*, Liu Siguo*. A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice. NPJ Vaccines. 2023 8(1):72.

3. Zhang Jiajun, Cui Yingying, Zang Xinxin, Feng Tingting, Chen Fanruo, Wang Hui, Dang Guanghui*, Liu Siguo*. PE12 interaction with TLR4 promotes intracellular survival of Mycobacterium tuberculosis by suppressing inflammatory response. International Journal of Biological Macromolecules. 2023 253(Pt 8):127547.

4. Tang Yangyang, Cui Yingying, Jiang Yanyan, Shao Mingzhu, Zang Xinxin, Dang Guanghui*, Liu Siguo*. Characteristics of Mycobacterium tuberculosis serine protease Rv1043c in enzymology and pathogenicity in mice. Journal of Integrative Agriculture. 2023 22(12):3755-3768.

5. Zang Xinxin#, Dang Guanghui#, Cai Zhuming, Shao Mingzhu, Tang Yangyang, Cao Jun, Cui Ziyin, Liu Siguo*. (2022). Extracellular DNase MAP3916c attacks the neutrophil extracellular traps and is needed for Mycobacterium avium subsp. paratuberculosis virulence. Veterinary microbiology. 2022, 273, 109529.

6. Cui Yingying#, Tang Yangyang#, Shao Mingzhu, Zang Xinxin, Jiang Yanyan, Cui Ziyin, Dang Guanghui*, Liu Siguo*. Mycobacterium tuberculosis protease Rv3090 is associated with late cell apoptosis and participates in organ injuries and mycobacterial dissemination in mice. Microbial pathogenesis, 2022, 173(Pt B), 105880.

7. Liu Hongxiu#, Dang Guanghui#, Zang Xinxin, Cai Zhuming, Song Ningning, Liu Siguo*. Characterization and pathogenicity of extracellular serine protease MAP3292c from Mycobacterium avium subsp. paratuberculosis. Microbial Pathogenesis. 2020, 142: 104055.

8. Li He#, Dang Guanghui#, Liu Hongxiu, Wang Zhongxing, Cui Ziyin, Song Ningning, Chen Liping, Liu Siguo. Characterization of a novel Mycobacterium tuberculosis serine protease (Rv3194c) activity and pathogenicity. Tuberculosis. 2019, 119:101880.

9. Dang Guanghui, Cui Yingying, Wang Lei, Li Tiantian, Cui Ziyin, Song Ningning, Chen Liping, Pang Hai, Liu Siguo*. Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Frontiers in immunology. 2018, 9:677.

10. Dang Guanghui, Cao Jun, Cui Yingying, Song Ningning, Chen Liping*, Pang Hai*, Liu Siguo*. Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis. Scientific Reports. 2016, 6:19033.

11. Dang Guanghui#, Chen Liping#, Li Zhaoli, Deng Xiaoxia, Cui Yingying, Cao Jun, Yu Shenye, Pang Hai*, Liu Siguo*. Expression, Purification and Characterisation of Secreted Esterase Rv2525c from Mycobacterium tuberculosis. Applied Biochemistry and Biotechnology. 2015, 176(1): 1-12.

12. Chen Liping#, Dang Guanghui#, Deng Xiaoxia, Cao Jun, Yu Shenye, Wu Defeng, Pang Hai*, Liu Siguo*. Characterization of a novel exported esterase Rv3036c from Mycobacterium tuberculosis. Protein Expression and Purification. 2014, 104: 50-56.

13. 陳凡若, 張嘉俊, 鹿萍, 崔寧, 崔瑩瑩, 崔子寅, 黨光輝*, 劉思國*. 副結(jié)核分枝桿菌免疫原蛋白的篩選及免疫保護效果評價[J]. 中國農(nóng)業(yè)科學(xué), 2024, 57 (06): 1204-1214.

14. 蔡珠明#, 黨光輝#, 臧鑫鑫, 邵明珠, 唐陽陽, 鹿萍, 崔瑩瑩, 崔子寅, 劉思國. 結(jié)核分枝桿菌復(fù)合群、副結(jié)核分枝桿菌和禽分枝桿菌禽亞種多重TaqMan熒光定量PCR方法的建立及初步應(yīng)用[J]. 中國預(yù)防獸醫(yī)學(xué)報, 2023, 45 (01): 51-59.

15. 陳凡若#, 黨光輝#, 張嘉俊, 鹿萍, 崔寧, 崔瑩瑩, 崔子寅, 劉思國. 結(jié)核分枝桿菌PE26蛋白調(diào)節(jié)巨噬細胞免疫反應(yīng)進而促進分枝桿菌胞內(nèi)定殖[J]. 中國預(yù)防獸醫(yī)學(xué)報, 2023, 45 (05): 502-509.

16. 臧鑫鑫#，黨光輝#，王忠星，劉虹秀，崔子寅，崔瑩瑩，宋寧寧，劉思國. 恥垢分支桿菌能夠誘導(dǎo)中性粒細胞胞外誘捕網(wǎng)的形成. 中國預(yù)防獸醫(yī)學(xué)報. 2019, 41(11): 1154-1158.

7、專利

1. 黨光輝，劉思國，蔡珠明，崔子寅. 一種同時檢測三種分枝桿菌的多重TaqMan熒光定量PCR試劑盒及其應(yīng)用. 專利號：ZL202110731289.4

2. 劉思國，黨光輝，陳利蘋，李田田. 一種牛副結(jié)核間接ELISA檢測試劑盒及其應(yīng)用. 專利號：ZL202310215284.5