1、個人簡歷
謝芳，女，博士，研究員，博士生導師，黑龍江省高層次E類人才。主要從事動物重要病原菌的致病機制、免疫機制及新型抗菌策略等研究。主持國家自然科學基金青年項目和面上項目、黑龍江省自然科學基金、中國農(nóng)業(yè)科學院基本科研業(yè)務費專項等科研項目。以第一作者或通訊作者在NPJ Biofilms and Microbiomes、Journal of Biological Chemistry等學術(shù)期刊發(fā)表文章20余篇；獲黑龍江省科學技術(shù)獎（第三完成人）、吉林省自然科學學術(shù)成果獎（第四完成人）、哈爾濱市科學技術(shù)獎（第三完成人）、中國商業(yè)聯(lián)合會科學技術(shù)獎（（第四完成人）；獲國家發(fā)明專利10項，參編著作1部。指導畢業(yè)研究生獲得“哈獸研一等獎學金”、“大華農(nóng)獎學金”等榮譽。
2、聯(lián)系方式
研究方向：獸醫(yī)微生物及其分子生物學
電話：0451-51051732
郵箱：xiefang@caas.cn
所在單位：中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所
通訊地址：哈爾濱市香坊區(qū)哈平路678號，150069
3、教育經(jīng)歷
2007.09-2010.06 吉林大學 預防獸醫(yī)學專業(yè) 博士
2005.09-2007.06 吉林大學 預防獸醫(yī)學專業(yè) 碩士
2001.09-2005.06 河北科技師范學院 動物醫(yī)學專業(yè) 學士
4、工作經(jīng)歷
2024.01-至今 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 研究員
2018.01-2023.12 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 副研究員
2010.07-2017.12 中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所 助理研究員
5、主持項目
1. 國家自然科學基金面上項目：豬鏈球菌2型半胱氨酸蛋白酶ApdS切割宿主防御肽cathelicidin LL-37介導其免疫逃逸的分子機制（31873016, 2019.01-2022.12）, 61萬元；
2. 國家自然科學基金青年科學基金項目：豬胸膜肺炎放線桿菌ClpP蛋白酶的致病機理研究（31100103, 2012.01-2014.12），24萬元；
3. 黑龍江省自然科學基金青年項目：豬鏈球菌2型SSU05_1311蛋白與纖連蛋白互作介導其黏附和侵入宿主細胞的分子機制（QC2016044, 2016.07-2019.07），5萬元；
4. 中國農(nóng)業(yè)科學院基本科研業(yè)務費專項：甲氧西林耐藥金黃色葡萄球菌抗菌新藥創(chuàng)制（1610302017007, 2017.01-2020.12）, 244萬元。
6、代表論文與著作
1. Huihui Zhang #, Xinyuan Zhang, Siyu Liang, Jing Wang, Yao Zhu, Wanjiang Zhang, Siguo Liu, Stefan Schwarz*, Fang Xie*. Bactericidal synergism between phage endolysin Ply2660 and cathelicidin LL-37 against vancomycin-resistant Enterococcus faecalis biofilms. NPJ Biofilms and Microbiomes. 2023, 9(1):16.
2. Mingjie Jin, Siyu Liang, Jing Wang, Huihui Zhang, Yueling Zhang, Wanjiang Zhang, Siguo Liu*, Fang Xie*. Endopeptidase O promotes Streptococcus suis immune evasion by cleaving the host-defence peptide cathelicidins, Virulence, 2023, 14(1):2283896.
3. Jing Wang, Siyu Liang, Xiaofeng Lu, Qiu Xu, Yao Zhu, Shenye Yu, Wanjiang Zhang, Siguo Liu*, Fang Xie*. Bacteriophage endolysin Ply113 as a potent antibacterial agent against polymicrobial biofilms formed by enterococci and Staphylococcus aureus. Frontiers in Microbiology. 2023,14:1304932.
4. Fang Xie, Yanan Zan, Xinyuan Zhang, Huihui Zhang, Mingjie Jin, Wanjiang Zhang, Yueling Zhang, Siguo Liu*. Differential abilities of mammalian cathelicidins to inhibit bacterial biofilm formation and promote multifaceted immune functions of neutrophils. International Journal of Molecular Sciences. 2020, 21(5):1871.
5. Fang Xie, Yanan Zan, Yueling Zhang, Ning Zheng, Qiulong Yan, Wanjiang Zhang, Huihui Zhang, Mingjie Jin, Fuguang Chen, Xinyuan Zhang, Siguo Liu*. The cysteine protease ApdS from Streptococcus suis promotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37. Journal of Biological Chemistry. 2019, 294(47): 17962-17977.
6. Fang Xie, Yalei Wang, Gang Li, Shuanghong Liu, Ning Cui, Siguo Liu, Paul R. Langford and Chunlai Wang. The SapA protein is involved in resistance to antimicrobial peptide PR-39 and virulence of Actinobacillus pleuropneumoniae. Frontiers in Microbiology. 2017, 8: 811.
7. Fang Xie, Gang Li, Yalei Wang, Yanhe Zhang, Long Zhou, Chengcheng Wang, Shuanghong Liu, Siguo Liu, Chunlai Wang. Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence. PLoS One. 2017, 12(4): e0176374.
8. Fang Xie, Gang Li, Long Zhou, Yanhe Zhang, Ning Cui, Siguo Liu, Chunlai Wang. Attenuated Actinobacillus pleuropneumoniae double-deletion mutant S-8?clpP/apxIIC confers protection against homologous or heterologous strain challenge. BMC Veterinary Research. 2017, 13(1): 14.
9. Gang Li#, Fang Xie#, Jianjun Li, Jiao Liu, Dapeng Li, Yanhe Zhang, Paul R. Langfordb, Yanwen Li, Siguo Liu, Chunlai Wang. Identification of novel Haemophilus parasuis serovar 5 vaccine candidates using an immunoproteomic approach. Journal of Proteomics.2017, 163: 111-117.
10. Fang Xie, Gang Li, Wanjiang Zhang, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang. Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of Actinobacillus pleuropneumoniae. Veterinary Microbiology. 2016, 183: 1-8,
11. Fang Xie, Gang Li, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang. The Lon protease homologue LonA, not LonC, contributes to the stress tolerance and biofilm formation of Actinobacillus pleuropneumoniae. Microbial Pathogenesis. 2016, 93: 38-43.
12. Fang Xie, Yanhe Zhang, Gang Li, Siguo Liu, Chunlai Wang. The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. PLoS One. 2013, 8(1): e53600.
13. FengYang#, Fang Xie#, Yuwen Jiang, Suqing Li, Yanping Xing, Yu Wang, Xin Feng, Wenyu Han, Liancheng Lei. Genomic Differences Between Actinobacillus pleuropneumoniae Serotypes 5b and 3 and their Distribution and Transcription Among 15 Serotypes. Current Microbiology. 2011, 63(4): 327-331.
14. Fang Xie, Liancheng Lei, Chongtao Du, Shuqing Li, Wenyu Han, Zhiyan Ren. Genomic differences between Actinobacillus pleuropneumoniae serotypes 1 and 3 and the diversity distribution among 15 serotypes. FEMS Microbiology Letters. 2010, 303(2): 147-155.
15. Fang Xie, Mingjun Zhang, Shuqing Li, Chongtao Du, Changjiang Sun, Wenyu Han, Liang Zhou, Liancheng Lei. Differentially expressed genes in the pathogenic strains of Actinobacillus pleuropneumoniae serotypes 1 and 3. Journal of Microbiology and Biotechnology. 2010, 20(4): 789-797.
16. Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu, Yueling Zhang. Streptococcus suis sortase A is Ca2+ independent and is inhibited by acteoside, isoquercitrin and baicalin. PLoS One. 2017, 12(3): e0173767.
17. Gang Li, Fang Xie, Yanhe Zhang, Janine T. Bossé, Paul R. Langford, and Chunlai Wang. Role of (p)ppGpp in viability and biofilm formation of Actinobacillus pleuropneumoniae S8. PLoS One. 2015, 10(10): e0141501.
18. Gang Li, Fang Xie, Yanhe Zhang, Chunlai Wang, Draft genome sequence of Actinobacillus pleuropneumoniae serotype 7 strain S-8. Journal of Bacteriology. 2012, 194(23): 6606-6607.
19. Mingming Hu, Yanhe Zhang, Fang Xie, Gang Li, Jianjun Li, Wei Si, Siguo Liu, Shouping Hu, Zhuo Zhang, Nan Shen, Chunlai Wang. Protection of piglets by a Haemophilus parasuis ghost vaccine against homologous challenge. Clin Vaccine Immunol, 2013, 20(6):795-802.
7、專利和標準
1. 謝芳，劉思國，張萬江，張躍靈，一種廣譜型抗菌肽及其應用，ZL 202010037156.2
2. 謝芳，王春來，張艷禾，李建軍，朱曉凱，李艷玲， 一種不含抗性標記的豬胸膜肺炎放線桿菌ClpP蛋白酶基因缺失株、其構(gòu)建方法及應用，ZL 201110336861.3
3. 王春來，謝芳，李剛，張艷禾，一種不含抗性標記的豬傳染性胸膜肺炎弱毒活疫苗及其用途，ZL 201310469680.7
4. 王春來，謝芳，張艷禾，李剛，一種不含抗性標記的豬胸膜肺炎放線桿菌雙基因缺失株、其構(gòu)建方法及應用，ZL 201110420236.7
5. 王春來，李剛，張艷禾，謝芳，一種副豬嗜血桿菌病亞單位疫苗組合物及應用，ZL 201310406551.3
6. 王春來，李剛，張艷禾，謝芳，一種制備副豬嗜血桿菌病菌影疫苗的方法及其產(chǎn)品和應用，ZL 201310409237.0
7. 王春來，李剛，張艷禾，謝芳， 一種副豬嗜血桿菌免疫保護性抗原AfuA，ZL 20131 0268347.X
8. 李剛，王春來，張艷禾，謝芳，一種副豬嗜血桿菌免疫保護性抗原HbpA，ZL 20131 0268864.7
9. 王春來，李剛，張艷禾，謝芳，一種副豬嗜血桿菌免疫保護性抗原OppA，ZL 20131 0268863.2
10. 王春來，李剛，張艷禾，謝芳，一種副豬嗜血桿菌免疫保護性抗原OppA2，ZL 20131 0268810.0
8、獲得獎勵
1. 豬傳染性胸膜肺炎菌影疫苗的研制及其應用，黑龍江省科技進步三等獎，王春來，李剛，謝芳，張艷禾，李艷玲，周瀧，2017年
2. 基于比較基因組學的胸膜肺炎放線桿菌黏附致病機制及異源免疫研究，吉林省自然科學學術(shù)成果獎二等獎，雷連成，馮新，楊舒心，謝芳，王瑜等，2014年
3. 豬傳染性胸膜肺炎菌影疫苗的研制及其應用，哈爾濱市科技進步二等獎，王春來，李剛，謝芳，張艷禾，李艷玲，周瀧，2016年
4. 豬傳染性胸膜肺炎綜合防控技術(shù)研究，中國商業(yè)聯(lián)合會科學技術(shù)三等獎，雷連成、李娜，王春來，謝芳，王磊等，2023年
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